Visceral Fat & Body Composition
Visceral adipose signalling is the principal focus of FS-TS1 research. The mechanism studied is GH-driven lipolysis in visceral depots, with limited effect on peripheral adipose depots.
● 10X TESTED · ISO 1702599%+ PURITYRESEARCH USE ONLY
FS-TS1
Growth Hormone Release Studies
MASS
QUANTITY
$90.00
$90.00/vial
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About this compound
FS-TS1 is a synthetic version of growth hormone releasing hormone, or GHRH. The sequence matches the full 44 amino acid human hormone. A chemical group added to one end protects it from an enzyme called DPP-4, which would otherwise break it down quickly. Research has measured growth hormone output and how fat tissue is distributed in study models.
Synthetic GHRH(1-44) analog (trans-3-hexenoic acid-modified)
- Formula
- C221H366N72O67S
- Molecular weight
- 5135.89 g/mol
- Form
- Lyophilized Powder
- CAS / ID
- 218949-48-5
0
Amino Acids
Full-length GHRH(1-44) analog
0
Research Material
mg per vial · Laboratory use only
0
Research Areas
Visceral Fat & Body Composition · Brain Structure & Function · GH/IGF-1 Axis & more
How It Works
How FS-TS1 works
The pathways FS-TS1 acts on — and what each one does. The animation traces its signal outward from the compound to every target it engages.
Signalling pathways studied in preclinical models · illustrative
Growth Hormone Secretagogue
GHRH-R Agonism
FS-TS1 is a synthetic trans-3-hexenoic acid–modified analog of human GHRH(1-44). It binds and activates pituitary GHRH receptors, stimulating endogenous growth hormone (GH) secretion while preserving normal pulsatile GH release patterns — unlike exogenous GH exposure.
- Selective GHRH receptor agonism
- Preserves pulsatile GH secretion physiology
- Downstream IGF-1 production measured
Visceral Adipose Signalling
Lipolysis
FS-TS1 is studied for GH-mediated lipolytic signalling in visceral adipose tissue. GH is associated with hormone-sensitive lipase activity in adipocytes and free fatty acid release from visceral depots. This material is supplied for laboratory research only and is not an approved pharmaceutical product.
- GH-dependent hormone-sensitive lipase activity measured
- Visceral depot selectivity
- Preserves lean body mass in research models
Cognitive & Brain Research
Neuroprotection
Research examines FS-TS1 in relation to brain structure and function via IGF-1 signalling. Studies in older adults with mild cognitive impairment report changes in regional grey matter volume and functional connectivity. GH/IGF-1 axis modulation is one hypothesised mechanism.
- Raised circulating IGF-1, which crosses the blood-brain barrier
- Associated with changes in cortical gray matter volume
- Under investigation for cognitive aging research models
Uses & Applications
What FS-TS1 is researched for
The main areas FS-TS1 is being studied for — and the study-reported figures behind them.
Brain Structure & Function
Regional brain volume and cognitive measures are a further area of research interest for this compound, studied via IGF-1 signalling.
GH/IGF-1 Axis
Research model for studying GHRH receptor pharmacology, GH secretagogue effects, and downstream IGF-1 modulation in the context of GH deficiency states and aging-related GH decline.
Lipid & Cardiovascular Markers
Studies report triglyceride, non-HDL cholesterol and carotid intima-media thickness measures in adult study populations, which is why the GH axis is studied against cardiovascular risk markers.
Molecular Structure
The FS-TS1 molecule
An interactive 3D model rendered from the compound record — rotate and explore its structure.
C221H366N72O67S
Compound Information
Full specification
| Chemical Name | Trans-3-hexenoic acid–GRF(1-44)-amide |
| Sequence | Modified GHRH(1-44) analog (44 amino acids) |
| Molecular Weight | 5135.8 Da |
| Molecular Formula | C₂₂₁H₃₆₆N₇₂O₆₇S |
| Form | Lyophilized powder |
| Purity | ≥99% (HPLC verified) |
| Testing | Third-party HPLC, Mass Spec, Endotoxin |
| Storage | -20°C for long-term stability |
| Solubility | Water-soluble |
| COA | Included with every order |
FAQ
Common questions about FS-TS1
FS-TS1 is a synthetic analog of human growth hormone–releasing hormone (GHRH), specifically a modified version of GHRH(1-44) with a trans-3-hexenoic acid group added to extend stability. Unlike exogenous growth hormone, FS-TS1 acts on the pituitary to release endogenous GH, preserving the pulsatile release pattern and the feedback regulation that exogenous GH bypasses.
No. FS-TS1 is supplied exclusively for in vitro laboratory research. It is not an approved pharmaceutical product and is not for human or veterinary use. The scientific encyclopedia and original laboratory COA retain the source compound identification.
FS-TS1 is studied for GH-mediated activation of hormone-sensitive lipase in visceral adipose depots specifically, rather than peripheral adipose depots. That depot selectivity is the property of research interest.
Emerging research is exploring FS-TS1's potential effects on brain structure and cognitive function via elevated IGF-1 signaling. Brain volume and verbal memory measures in cognitive models are an active area of investigation for this compound.
FS-TS1 is not approved for human use and this material is supplied exclusively for in vitro laboratory research. Handling precautions are the same as for any research peptide; no human safety profile is offered for the material sold here.
Lyophilized FS-TS1 should be stored at -20°C and protected from moisture and light. The trans-3-hexenoic acid modification raises resistance to dipeptidyl peptidase IV (DPP-IV) cleavage compared to native GHRH, but the material should still be handled carefully to preserve biological activity.
Research Use Only.
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA; this product is not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively to qualified researchers and institutions.