Molecular data
| Molecular formula | C221H366N72O67S |
|---|---|
| Molecular weight | 5135.89 Da |
| Sequence | Modified GHRH(1-44) analog (trans-3-hexenoic acid-GRF(1-44)-amide) |
| Sequence length | 44 residues |
| CAS / identifier | 218949-48-5 |
| Physical form | Lyophilized Powder |
| Available sizes | 10mg |
How it works
Growth Hormone Secretagogue
FS-TS1 is a synthetic trans-3-hexenoic acid–modified analog of human GHRH(1-44). It binds and activates pituitary GHRH receptors, stimulating endogenous growth hormone (GH) secretion while preserving normal pulsatile GH release patterns — unlike exogenous GH exposure.
- Selective GHRH receptor agonism
- Preserves pulsatile GH secretion physiology
- Downstream IGF-1 production measured
Visceral Adipose Signalling
FS-TS1 is studied for GH-mediated lipolytic signalling in visceral adipose tissue. GH is associated with hormone-sensitive lipase activity in adipocytes and free fatty acid release from visceral depots. This research material is not an approved pharmaceutical product.
- GH-dependent hormone-sensitive lipase activity measured
- Visceral depot selectivity
- Preserves lean body mass in research models
Cognitive & Brain Research
Research examines FS-TS1 in relation to brain structure and function via IGF-1 signalling. Studies in older adults with mild cognitive impairment report changes in regional grey matter volume and functional connectivity. GH/IGF-1 axis modulation is one hypothesised mechanism.
- Raised circulating IGF-1, which crosses the blood-brain barrier
- Associated with changes in cortical gray matter volume
- Under investigation for cognitive aging research models
What the research shows
Visceral Fat & Body Composition
Visceral adipose signalling is the principal focus of FS-TS1 research. The mechanism studied is GH-driven lipolysis in visceral depots, with limited effect on peripheral adipose depots.
Brain Structure & Function
Regional brain volume and cognitive measures are a further area of research interest for this compound, studied via IGF-1 signalling.
GH/IGF-1 Axis
Research model for studying GHRH receptor pharmacology, GH secretagogue effects, and downstream IGF-1 modulation in the context of GH deficiency states and aging-related GH decline.
Lipid & Cardiovascular Markers
Studies report triglyceride, non-HDL cholesterol and carotid intima-media thickness measures in adult study populations, which is why the GH axis is studied against cardiovascular risk markers.
Specification
| Chemical Name | Trans-3-hexenoic acid–GRF(1-44)-amide |
|---|---|
| Sequence | Modified GHRH(1-44) analog (44 amino acids) |
| Molecular Weight | 5135.8 Da |
| Molecular Formula | C₂₂₁H₃₆₆N₇₂O₆₇S |
| Form | Lyophilized powder |
| Purity | ≥99% (HPLC verified) |
| Testing | Third-party HPLC, Mass Spec, Endotoxin |
| Storage | -20°C for long-term stability |
| Solubility | Water-soluble |
| COA | Included with every order |
Frequently asked questions
What is FS-TS1 and how is it different from growth hormone?
FS-TS1 is a synthetic analog of human growth hormone–releasing hormone (GHRH), specifically a modified version of GHRH(1-44) with a trans-3-hexenoic acid group added to extend stability. Unlike exogenous growth hormone, FS-TS1 acts on the pituitary to release endogenous GH, preserving the pulsatile release pattern and the feedback regulation that exogenous GH bypasses.
How is FS-TS1 characterised in visceral adipose research?
FS-TS1 is studied for GH-mediated activation of hormone-sensitive lipase in visceral adipose depots specifically, rather than peripheral adipose depots. That depot selectivity is the property of research interest.
What is the cognitive research interest in FS-TS1?
Emerging research is exploring FS-TS1's potential effects on brain structure and cognitive function via elevated IGF-1 signaling. Brain volume and verbal memory measures in cognitive models are an active area of investigation for this compound.
What is FS-TS1's regulatory status?
FS-TS1 is not approved for human use and this material is supplied exclusively for in vitro laboratory research. Handling precautions are the same as for any research peptide; no human safety profile is offered for the material sold here.
How should research-grade FS-TS1 be stored?
Lyophilized FS-TS1 should be stored at -20°C and protected from moisture and light. The trans-3-hexenoic acid modification raises resistance to dipeptidyl peptidase IV (DPP-IV) cleavage compared to native GHRH, but the material should still be handled carefully to preserve biological activity.
For laboratory research use only. Not a drug, supplement, or medical product; not for human or animal use. All findings referenced are from published preclinical/laboratory research.